Officers responded to reports of a burglary at a business in Dandenong South around 3am this morning.
When police got to the premises, a Toyota Hiace van allegedly rammed into the police van on Langley Street.
“A short scuffle has occurred between the two male offenders and two police officers, before the offenders fled in the Hiace van,” Victoria Police said.
Police allege one of the officers was bitten on the arm and punched in the head multiple times during the scuffle.
He was taken to hospital for treatment.
After fleeing the scene, the van collided with a Audi A3 on Alma Road, St Kilda East, around 7am.
The offending driver, a 28-year-old Dandenong man, sustained serious injuries while his passenger, a 32-year-old Mornington man, suffered minor injuries.
Both men were trapped in the van before emergency services extricated them and they were taken to hospital.
The pair remain in hospital under police guard.
The Audi driver suffered minor injuries and was treated at the scene.